Appliqué à une dose de 12,5 à 200 mcg 1 fois / jour 20 à 30 minutes avant les repas. Réglez individuellement en fonction des indications. Il est nécessaire d’observer strictement la conformité de la forme posologique utilisée d’un médicament particulier avec les indications d’utilisation et le schéma posologique. Le schéma posologique optimal est déterminé par le médecin. La méthode d’application et le schéma posologique d’un médicament particulier dépendent de sa forme de libération et d’autres facteurs.

When using sertraline in patients with hypothyroidism, it is possible to reduce the effects of levothyroxine sodium. When ritonavir is used, the need for levothyroxine may increase. Sucralfate, aluminum hydroxide, calcium carbonate reduce the absorption of levothyroxine from the gastrointestinal tract.Ĭholestyramine reduces the absorption of levothyroxine sodium from the gastrointestinal tract. Salicylates, dicumarin, furosemide (250 mg), clofibrate can displace levothyroxine from its connection with plasma proteins. In patients with hypothyroidism and concomitant diabetes mellitus, at the beginning of replacement therapy with thyroid hormone drugs, an increase in the need for insulin or oral hypoglycemic agents is possible. Levothyroxine sodium potentiates the action of indirect anticoagulants (coumarin derivatives), reduces the effectiveness of oral hypoglycemic agents. In some cases, thyroid hormones can cause or aggravate the previous myasthenic syndrome. When conducting a differential diagnostic test of thyroid suppression, patients with diabetes mellitus are advised to increase the dose of antidiabetic agents. Use with caution in diabetes mellitus and diabetes insipidus. In this case, GCS replacement therapy should be started before starting treatment for hypothyroidism with thyroid hormones in order to avoid the development of acute adrenal insufficiency. In hypothyroidism caused by damage to the pituitary gland, it is necessary to find out whether there is simultaneously an adrenal cortex insufficiency. In such cases, levothyroxine sodium should be used at a low initial dose, increasing it slowly and at long intervals. Use with extreme caution in patients with cardiovascular diseases (including coronary artery disease, heart failure, arterial hypertension). In elderly patients and with prolonged hypothyroidism, treatment should be started gradually. It is possible to use in children according to indications in doses and dosage forms recommended according to age. Use in combination with thyrostatic agents during pregnancy is contraindicated due to the increased risk of hypothyroidism in the fetus. With care: in case of diseases of the cardiovascular system – ischemic heart disease (atherosclerosis, angina pectoris, a history of myocardial infarction), arterial hypertension, arrhythmias with diabetes mellitus, severe long-term hypothyroidism, malabsorption syndrome (dose adjustment may be required).Īpplication during pregnancy and lactationĭuring pregnancy and lactation (breastfeeding), levothyroxine sodium should be used with caution, strictly in recommended doses, under medical supervision. Hypersensitivity to levothyroxine sodium untreated thyrotoxicosis acute myocardial infarction, acute myocarditis untreated adrenal insufficiency. Symptoms of hyperthyroidism: possible (when used in high doses, including when the dose is increased too quickly at the beginning of the course of treatment) tachycardia, palpitation, arrhythmias, angina attacks, headache, nervousness, tremors, sleep disturbances, feeling of internal anxiety, muscle weakness and cramps, weight loss, diarrhea, menstrual irregularities, vomiting. When conducting a differential diagnostic test of thyroid suppression – once in a dose of 3 mg or within 2 weeks, 200 μg 1 time / day. Applied at a dose of 12.5-200 mcg 1 time / day 20-30 minutes before meals. Set individually depending on the indications. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen. The optimal dosage regimen is determined by the doctor. The method of application and dosage regimen of a particular drug depends on its form of release and other factors.

Levothyroxine 100 mcg